EOCOPD: Early Onset COPD Study

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A, Ruppert A, Lødrup Carlsen KC, Roses A, Anderson W, Rennard SI, Lomas DA, Silverman EK, Goldstein DB; ICGN Investigators. PLoS Genet. 2009 Mar;5(3):e1000421. Epub 2009 Mar 20.

Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Kim WJ, Hersh CP, DeMeo DL, Reilly JJ, Silverman EK. Respir Med. 2009 Apr;103(4):552-7. Epub 2008 Dec 25.

Computed tomography phenotypes in severe, early-onset chronic obstructive pulmonary disease. Hersh CP, Jacobson FL, Gill R, Silverman EK. COPD. 2007 Dec;4(4):331-7.

Genetic linkage and association analysis of COPD-related traits on chromosome 8p. Hersh CP, DeMeo DL, Raby BA, Litonjua AA, Sylvia JS, Sparrow D, Reilly JJ, Silverman EK. COPD. 2006 Dec;3(4):189-94.

Genetic determinants of C-reactive protein in COPD. Hersh CP, Miller DT, Kwiatkowski DJ, Silverman EK. Eur Respir J. 2006 Dec;28(6):1156-62. Epub 2006 Sep 13.

The SERPINE2 gene is associated with chronic obstructive pulmonary disease. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. Proc Am Thorac Soc. 2006 Aug;3(6):502.

Progress in chronic obstructive pulmonary disease genetics. Silverman EK. Proc Am Thorac Soc. 2006 Jul;3(5):405-8.

Predictors of survival in severe, early onset COPD. Hersh CP, DeMeo DL, Al-Ansari E, Carey VJ, Reilly JJ, Ginns LC, Silverman EK. Chest. 2004 Nov;126(5):1443-51.

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK. Hum Mol Genet. 2004 Aug 1;13(15):1649-56. Epub 2004 Jun 2.

Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD. DeMeo DL, Carey VJ, Chapman HA, Reilly JJ, Ginns LC, Speizer FE, Weiss ST, Silverman EK. Thorax. 2004 May;59(5):396-400.

Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. Am J Hum Genet. 2002 May;70(5):1229-39. Epub 2002 Mar 25.

Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. Hum Mol Genet. 2002 Mar 15;11(6):623-32.

Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. Silverman EK, Weiss ST, Drazen JM, Chapman HA, Carey V, Campbell EJ, Denish P, Silverman RA, Celedon JC, Reilly JJ, Ginns LC, Speizer FE. Am J Respir Crit Care Med. 2000 Dec;162(6):2152-8.

Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O'DONNELL WJ, Reilly JJ, Ginns L, Mentzer S, Wain J, Speizer FE. Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1770-8.

Risk factors for the development of chronic obstructive pulmonary disease. Silverman EK, Speizer FE. Med Clin North Am. 1996 May;80(3):501-22.

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